Article

Intergenerational and life-course links between a cardiovascular health-related methylation score and early vascular changes

2026-08-10

Abstract excerpt

<h4>Background</h4> DNA methylation (DNAm) may capture cumulative genetic, environmental, and lifestyle influences on cardiovascular health. Composite DNAm score based on the American Heart Association Life’s Essential 8 (LE8) framework have been linked to clinical events, but their association with early vascular changes and intergenerational effects is unclear. <h4>Methods</h4> We studied up to 1432 participan...

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Literature Corpus work: c1fa6421-d626-5f66-b560-c4a92ded37c6
DOI: 10.64898/2026.08.07.26359994

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