Article

A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19

2020-06-23

Abstract excerpt

A high-throughput platform would greatly facilitate COVID-19 serological testing and antiviral screening. Here we report a nanoluciferase SARS-CoV-2 (SARS-CoV-2-Nluc) that is genetically stable and replicates similarly to the wild-type virus in cell culture. We demonstrate that the optimized reporter virus assay in Vero E6 cells can be used to measure neutralizing antibody activity in patient sera and produces res...

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Identifiers and source

Literature Corpus work: ce222294-64e2-5dec-ae9f-99ad06ea5b72
DOI: 10.1101/2020.06.22.165712

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