Article

Safety and pathovariant-independent susceptibility in a <i>Salmonella</i> Typhimurium controlled human infection model: a phase 1, randomised, double-blind, dose-escalation study

2026-07-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Invasive non-typhoidal Salmonella (iNTS) disease causes an estimated 605,000 cases and 76,000 deaths each year, concentrated in sub-Saharan Africa, where the African Salmonella Typhimurium sequence type 313 (ST313) lineage predominates. Vaccine development is hampered by an absence of efficacy data and undefined correlates of protection. <h4>Methods</h4> We conducted a p...

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Literature Corpus work: c17ecdc4-e797-5b6f-a1fc-1ab4fc04ffa3
DOI: 10.64898/2026.07.23.26358774

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