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Article

Safety and immunogenicity of the invasive non-typhoidal Salmonella (iNTS)-GMMA vaccine: a first-in-human, randomised, dose escalation trial

1 Sept 2025

Abstract excerpt

BACKGROUND: Invasive non-typhoid Salmonella (iNTS) is a leading cause of morbidity and mortality in sub-Saharan Africa. We assess the safety and immunogenicity of an outer membrane vesicle vaccine (iNTS-GMMA) derived from the two most common serovars, S. Enteritidis (SEn) and S. Typhimurium (STm). METHODS: This single centre, randomised within cohort, placebo-controlled dose escalation single-blind with blinded...

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Identifiers

PMID: 40907249
DOI: 10.1016/j.ebiom.2025.105903

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