Contrasting prognostic role of KEAP1-NFE2L2-CUL3 mutation in human Uterine Corpus Endometrial Carcinoma (UCEC)

Abstract excerpt

<title>Abstract</title> <p>Uterine corpus endometrial cancer (UCEC) is a third most common malignancy in women with a poor prognosis in advanced stages. In this study, we performed an integrated comparative analysis of exome and transcriptome data from The Cancer Genome Atlas (TCGA), Lung Adenocarcinoma (LUAD), and UCEC patients. Our multi-omics analysis shows that the UCEC patients carrying mutations in the <ita...

Topics

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• Biomarkers, Tumor
• Cullin Proteins
• Endometrial Neoplasms
• Gene Expression Regulation, Neoplastic
• Glutathione
• Kelch-Like ECH-Associated Protein 1
• NF-E2-Related Factor 2
• Reactive Oxygen Species

Identifiers and source

Literature Corpus work

c172b6c2-2800-5353-82cb-bf4dc557effa

DOI

10.21203/rs.3.rs-3845100/v1