Article

PLK1 inhibition enhances gemcitabine-induced apoptosis through PLK1-dependent ERK1/2-BIM and AKT1/NOXA signals in pancreatic cancer cells

2025-07-28

Abstract excerpt

<title>Abstract</title> <p><bold>Background and Objective</bold>:Polo-like kinase 1 (PLK1) is a critical regulator of many cell cycle events, which has been found to be associated with resistance to cytotoxic drugs. In the present study, we investigates whether PLK1 regulates the sensitivity of pancreatic cancer cells to Gemcitabine (GEM) and its mechanism.<bold>Methods</bold>:We detected the expression of PLK1 i...

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Literature Corpus work: c169ef6b-b5f1-5598-93ea-246cc2ce7b7b
DOI: 10.21203/rs.3.rs-7181022/v1

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