Article

Structural basis of anti-SARS-CoV-2 activity of HCQ: specific binding to N protein to disrupt its interaction with nucleic acids and LLPS

2021-06-20

Abstract excerpt

<title>Abstract</title> <p>Great efforts have led to successfully developing the spike-based vaccines but challenges still exist to completely terminate the SARS-CoV-2 pandemic. SARS-CoV-2 nucleocapsid (N) protein plays the essential roles in almost all key steps of the viral life cycle, thus representing a top drug target. Almost all key functions of N protein including liquid-liquid phase separation (LLPS) depe...

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Literature Corpus work: c14e318d-2c59-5473-b31f-58edbc7f1a75
DOI: 10.21203/rs.3.rs-621646/v1

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