Article

Analyzing Machupo virus-receptor binding by molecular dynamics simulations

2014-01-27

Abstract excerpt

In many biological applications, we would like to be able to computationally predict mutational effects on affinity in protein-protein interactions. However, many commonly used methods to predict these effects perform poorly in important test cases. In particular, the effects of multiple mutations, nonalanine substitutions, and flexible loops are difficult to predict with available tools and protocols. We presen...

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Identifiers and source

Literature Corpus work: c130c358-5113-5244-bc41-0321a89d1baa
DOI: 10.7287/peerj.preprints.138v3

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