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A cattle-derived human H5N1 isolate suppresses innate immunity despite efficient replication in human respiratory organoids

2025-11-02

Abstract excerpt

<h4>Summary</h4> The H5N1 high pathogenicity avian influenza virus (HPAIV) of clade 2.3.4.4b, which spreads globally via wild birds, has become a major public health concern because it can infect a variety of mammals, including humans. In 2024, infection of dairy cattle with H5N1 HPAIV clade 2.3.4.4b was confirmed in the United States, and subsequent human cases were reported. Although these viruses are highly pa...

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Literature Corpus work
c0dc408e-3491-526a-9e42-c090af37d32c
DOI
10.1101/2025.11.02.684669
Open publication

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A cattle-derived human H5N1 isolate suppresses innate immunity despite efficient replication in human respiratory organoidsDOI 10.1101/2025.11.02.684669
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