Article

Preclinical Safety and Tolerability of an AAV Vector Expressing TLR9 in Mice and Hamsters

2026-01-13

Abstract excerpt

<title>Abstract</title> <p> Toll-like receptor 9 (TLR9) is an innate DNA sensor that activates pro-inflammatory pathways and contributes to the maturation of antigen presenting cells. TLR9 deficiency has been implicated in impaired tumor immunosurveillance and attenuated responsiveness to immune checkpoint blockade. We developed an adeno-associated virus (AAV) vector encoding TLR9 to restore receptor expression...

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Literature Corpus work: c0a2bbdb-8c08-510d-84d5-71459fb786c6
DOI: 10.21203/rs.3.rs-8545024/v1

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