Article

Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation

2025-03-17

Abstract excerpt

Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic data of individuals with European ancestry, introducing potential biases that remain uncharacterized. Here, we generate over 800 million full-length reads with long-read RNA-seq in 43 lymphoblastoid cell line samples...

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Literature Corpus work: c02ecf29-9e5a-5127-8477-cf80e04650f4
DOI: 10.1101/2025.03.14.643250

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