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Cysteine proteases of human hookworm <i>Necator Americanus as virulence</i> factors and implications for drug design with anti-heparin and heparin analogs: A bioinformatics study

2017-03-17

Abstract excerpt

Human hookworm Necator Americanus (NA) causes iron deficiency anemia, as the parasite ingests blood from the gastrointestinal tract of its human host. This bioinformatics-based study focuses on eight of the cathepsin B-like cysteine proteases (CPs) of the worm to explore their pathogenic potential. CP1 - CP6, which harbored the active site cysteine residue for enzymatic activity, were relevantly observed to have...

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Literature Corpus work: c00b8acb-bc0e-5ad5-8bd4-cb4dca6f8933
DOI: 10.1101/116921

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Cysteine proteases of human hookworm <i>Necator Americanus as virulence</i> factors and implications for drug design with anti-heparin and heparin analogs: A bioinformatics studyDOI 10.1101/116921Read

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