Transfection of Hypoxia-Inducible Factor-1α mRNA Upregulates the Expression of Genes Encoding Angiogenic Growth Factors

Abstract excerpt

<title>Abstract</title> <p>Hypoxia-Inducible Factor-1α (HIF-1α) has presented a new direction for ischemic preconditioning of surgical flaps to promote their survival. In a previous study, we demonstrated the effectiveness of HIF-1a DNA plasmids in this application. In this study, to avoid complications associated with plasmid use, we sought to express HIF-1α through mRNA transfection and determine its biological...

Topics

Open a Topic to create a Post that cites this publication.

• Angiogenesis and VEGF in Cancer
• Autophagy in Disease and Therapy
• Cancer, Hypoxia, and Metabolism
• Electrospun Nanofibers in Biomedical Applications
• Heme Oxygenase-1 and Carbon Monoxide
• High Altitude and Hypoxia
• Mesenchymal stem cell research
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

c0065a40-eff3-5877-b992-b608f369c9ca

DOI

10.21203/rs.3.rs-3064707/v1