Article

Radiprodil, a selective GluN2B negative allosteric modulator, rescues audiogenic seizures in mice carrying the GluN2A(N615S) mutation

2023-07-25

Abstract excerpt

<h4>Background: </h4> and Purpose: GRIN-related disorders are neurodevelopmental disorders caused by mutations in the N-methyl-D-aspartate receptor (NMDAR) subunit receptor GRIN genes. A large fraction of these mutations leads to gain of function (GoF) of the NMDAR. Patients present with a combination of symptoms that includes epilepsy, intellectual disability, behavioural and motor symptoms. Controlling seizures...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bfe84aee-fd96-5f7e-8d4f-18af3efb48b5
DOI: 10.22541/au.169028585.52171833/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Radiprodil, a selective GluN2B negative allosteric modulator, rescues audiogenic seizures in mice carrying the GluN2A(N615S) mutationDOI 10.22541/au.169028585.52171833/v1Read

Radiprodil, a selective GluN2B negative allosteric modulator, rescues audiogenic seizures in mice carrying the GluN2A(N615S) mutation.Semantic proximity Read

Disruption of grin2A , an epilepsy-associated gene, produces altered spontaneous swim behavior in zebrafishSemantic proximity Read

β-hydroxybutyrate improves convulsions in mice carrying the GRIN1 Y647S/+ pathogenic variantSemantic proximity Read

Modeling and treating GRIN2A developmental and epileptic encephalopathy in miceSemantic proximity Read

Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutationSemantic proximity Read

Altered GluN2A levels reduce the emergence of seizure-like events in a rat model of GRIN2A haploinsufficiencySemantic proximity Read

Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation.Semantic proximity Read

Functional Investigation of a GRIN2A Variant Associated with Rolandic Epilepsy.Semantic proximity Read

A gain-of-function GRIA2 variant associated with neurodevelopmental delay and seizures: functional characterization and targeted treatmentSemantic proximity Read

Positive allosteric modulators that target NMDA receptors rectify loss-of-function GRIN variants associated with neurological and neuropsychiatric disorders.Semantic proximity Read

GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia.Semantic proximity Read