Article

Evaluation of 177Lu-PSMA-617 Based Targeted Radioligand Therapy with X-Ray Stimulated PSMA Relocation in the PiggyBac Reporter Gene Engineered Orthotopic Prostate Tumor Model

2026-03-31

Abstract excerpt

Because human prostate cancer (PCa) grows slowly, establishing PCa tumor models is often time-consuming and unpredictable, limiting the efficiency of preclinical theranostic development. To address this, we used a non-viral PiggyBac transposon system to introduce triple reporter genes into PSMA-expressing C4-2 cells, generating orthotopic and subcutaneous xenograft models that allow noninvasive, real-time monitori...

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Literature Corpus work: bf691e40-ba91-5e12-b8ee-0ad4634a4891
DOI: 10.20944/preprints202603.2479.v1

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Evaluation of 177Lu-PSMA-617 Based Targeted Radioligand Therapy with X-Ray Stimulated PSMA Relocation in the PiggyBac Reporter Gene Engineered Orthotopic Prostate Tumor ModelDOI 10.20944/preprints202603.2479.v1Read

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