Article

Beyond Glycogen Storage: AMPKγ2 Regulates Cardiac Hypertrophy and Electrophysiology via Myosin Interaction

2026-04-23

Abstract excerpt

<h4>Introduction</h4> Variants in PRKAG2 cause hypertrophic cardiomyopathy (HCM) and conduction disturbances. While prior studies associated PRKAG2 -related hypertrophy with increased glycogen storage, many HCM phenotypes remain unexplained. We aimed to uncover how PRKAG2 variants induce myocyte hypertrophy and electrical changes during early cardiac development. <h4>Methods</h4> We generated transgenic zebr...

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Literature Corpus work: bf58c901-a971-58bd-8006-a45ee4c9b9f8
DOI: 10.64898/2026.04.20.719766

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