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Article

Establishment of a PRKAG2 cardiac syndrome disease model and mechanism study using human induced pluripotent stem cells.

Journal of molecular and cellular cardiology - 1 Apr 2018

Zhan Yongkun, Sun Xiaolei, Li Bin, Cai Huanhuan, Xu Chen, Liang Qianqian, Lu Chao, Qian Ruizhe, Chen Sifeng, Yin Lianhua, Sheng Wei, Huang Guoying, Sun Aijun, Ge Junbo, Sun Ning

Abstract excerpt

PRKAG2 cardiac syndrome is a distinct form of human cardiomyopathy characterized by cardiac hypertrophy, ventricular pre-excitation and progressive cardiac conduction disorder. However, it remains unclear how mutations in the PRKAG2 gene give rise to such a complicated disease. To investigate the underlying molecular mechanisms, we generated disease-specific hiPSC-derived cardiomyocytes from two brothers both...

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Source

Identifiers

PMID: 29452156
DOI: 10.1016/j.yjmcc.2018.02.007

Genes

PRKAG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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