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Article

Early-Onset Osteoporosis: Molecular Analysis in Large Cohort and Focus on the PLS3 Gene.

Calcified tissue international - 1 Nov 2024

Mancini Maxence, Chapurlat Roland, Isidor Bertrand, Desjonqueres Marine, Couture Guillaume, Guggenbuhl Pascal, Coutant Régis, El Chehadeh Salima, Fradin Mélanie, Frazier Aline, Goldenberg Alice, Guillot Pascaline, Koumakis Eugénie, Mehsen-Cêtre Nadia, Rossi Massimiliano, Schaefer Élise, Sigaudy Sabine, Porquet-Bordes Valérie, Fontanges Élisabeth, Letard Pauline, Edouard Thomas, Javier Rose-Marie, Cohen-Solal Martine, Funck-Brentano Thomas, Collet Corinne

Abstract excerpt

Osteoporosis is a skeletal disorder characterized by abnormal bone microarchitecture and low bone mineral density (BMD), responsible for an increased risk of fractures and skeletal fragility. It is a common pathology of the aging population. However, when osteoporosis occurs in children or young adults, it strongly suggests an underlying genetic etiology. Over the past two decades, several genes have been...

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Source

Identifiers

PMID: 39316135
DOI: 10.1007/s00223-024-01288-z

Genes

PLS3
LRP5
COL1A1
COL1A2
LRP6
WNT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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