Article
Alpha-crystallins and tumorigenesis.
Current molecular medicine - 1 Nov 2012
Chen P, Ji W, Liu F-Y, Tang H-Z, Fu S, Zhang X, Liu M, Gong L, Deng M, Hu W-F, Hu X-H, Chen X-W, Li Z-L, Li X, Liu J, Li D W-C
Abstract excerpt
αA- and αB-crystallins, the major lens structure proteins and members of the small heat-shock proteins (sHSPs) family, play essential roles in maintaining normal cellular structure and physiology of both ocular and some non-ocular tissues. Mutations and abnormal expression of these sHSPs are associated with various human diseases such as cataract, neural disorders, and cardiovascular diseases. In addition, recent...
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