Article

A multitask single-cell analysis framework with knowledge graph as a prior

2026-04-29

Abstract excerpt

<h4>ABSTRACT</h4> Single-cell RNA sequencing has reshaped cancer biology by revealing the cellular and molecular diversity of the tumor microenvironment, yet most analysis pipelines still treat clustering, annotation, pathway scoring, metabolic inference, and cell–cell communication as separate tasks. Here, we present scKNIFE (Knowledge graph-based NMF for Inference of Functional Entities), a unified graph-regula...

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Literature Corpus work: be67ee3c-30aa-5548-aa29-1710b015c6cc
DOI: 10.64898/2026.04.25.720773

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