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Roles for Microglia in Cryptococcal Brain Dissemination in the Zebrafish Larva

31 Jan 2023

Abstract excerpt

crosses the blood-brain barrier will be crucial to understanding and possibly preventing brain infection. Using the zebrafish larva as a model host, we show that microglia, the resident phagocytes of the brain, potentially play multiple previously unappreciated roles in cryptococcal infection of the brain. These roles include reinforcing the integrity of the blood-brain barrier, clearing cryptococcal cells after...

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PMID: 36719205
DOI: 10.1128/spectrum.04315-22

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