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Article

Bacterial peptidoglycan serves as a critical modulator of the gut-immune-brain axis in Drosophila

6 May 2024

Abstract excerpt

• In line with our prior studies in mice, gut bacteria-derived PGN fragments disseminate and reach the Drosophila brain. • Sensing of circulating PGN fragments triggers immune and stress signaling pathways in the central nervous system. • Gut derived PGN fragments primarily induce an inflammatory response in perineurial glia at the brain-circulation interface. • Continuous activation of immune signaling in...

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PMID: 38710338
DOI: 10.1016/j.bbi.2024.05.009

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