Article
A mutation in desmin makes skeletal muscle less vulnerable to acute muscle damage after eccentric loading in rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2021
Langer Henning T, Mossakowski Agata A, Avey Alec M, Wohlgemuth Ross P, Smith Lucas R, Zbinden-Foncea Herman, Baar Keith
Abstract excerpt
Desminopathy is the most common intermediate filament disease in humans. The most frequent mutation causing desminopathy in patients is a R350P DES missense mutation. We have developed a rat model with an analogous mutation in R349P Des. To investigate the role of R349P Des in mechanical loading, we stimulated the sciatic nerve of wild-type littermates (WT) (n = 6) and animals carrying the mutation (MUT) (n = 6)...
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