Article
In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses.
Scientific reports - 19 Jun 2015
Schmier Sonja, Mostafa Ahmed, Haarmann Thomas, Bannert Norbert, Ziebuhr John, Veljkovic Veljko, Dietrich Ursula, Pleschka Stephan
Abstract excerpt
Newly emerging influenza A viruses (IAV) pose a major threat to human health by causing seasonal epidemics and/or pandemics, the latter often facilitated by the lack of pre-existing immunity in the general population. Early recognition of candidate pandemic influenza viruses (CPIV) is of crucial importance for restricting virus transmission and developing appropriate therapeutic and prophylactic strategies...
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