Article
Towards establishing correlates of protection against shigellosis: assessing immunological endpoints across immune responses to the Shigella sonnei Generalized Modules for Membrane Antigens (GMMA) candidate vaccine (1790GAHB).
2023-09-21
Abstract excerpt
<title>Abstract</title> <p><italic>Shigella</italic> spp. are a leading bacterial cause of diarrhea. No widely licensed vaccines are available and there is no generally accepted correlate of protection. We tested a <italic>S. sonnei</italic> Generalized Modules for Membrane Antigen (GMMA)-based vaccine (1790GAHB) in a phase 2b, placebo-controlled, randomized, controlled human infection model study (NCT03527173) e...
Topics
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- Bacteriophages and microbial interactions
- Clostridium difficile and Clostridium perfringens research
- Escherichia coli research studies
- Hepatitis Viruses Studies and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Viral gastroenteritis research and epidemiology
- Zoonotic diseases and public health
Identifiers and source
- Literature Corpus work
- bd9df88e-df86-502b-946c-8b0eadaf3589
- DOI
- 10.21203/rs.3.rs-3314985/v1
