Article

Towards establishing a correlate of protection against shigellosis: assessing immunological endpoints across immune responses to the Shigella sonnei 1790GAHB GMMA investigational vaccine

2023-07-11

Abstract excerpt

<title>Abstract</title> <p><italic>Shigella</italic> spp. are a leading bacterial cause of diarrhea. No widely licensed vaccines are available and there is no generally accepted correlate of protection. We tested a <italic>S. sonnei</italic> GMMA-based vaccine (1790GAHB) in a phase 2b, placebo-controlled, randomized, controlled human infection model study (NCT03527173) enrolling healthy US adults aged 18–50 years...

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Literature Corpus work: 3dcbda5a-a09b-5637-8c34-b3af657448e1
DOI: 10.21203/rs.3.rs-3088906/v1

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