Article

Fragile dynamics enable diverse genomic determinants to influence arrhythmia propensity

2017-01-18

Abstract excerpt

Genotype-phenotype relationships are determinants of human diseases. Often, we know little about why so many genes are involved in complex common diseases. We hypothesized that this multigene effect arises from the relationship between genes and physiological dynamics. We tested this hypothesis for arrhythmias as physiological dynamics define this disease. We integrated graph theory analysis of genomic and protein...

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Identifiers and source

Literature Corpus work: bd218307-ba4b-51a0-a45a-3fe67b42d8e1
DOI: 10.1101/101162

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