Article

G-CSF and IL-6 drive myeloid dysregulation during severe viral infection

2024-09-14

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulated myeloid states are associated with disease severity in both sepsis and COVID-19. However, their relevance in non-COVID-19 viral infection, the factors driving their induction, and their role in tissue injury remain poorly understood. We performed a meta-analysis of 1,622,180 myeloid cells from 890 COVID-19 or sepsis patients and controls across 19 published blood scRNA-seq datasets,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bc96adc4-79c6-51b1-8dd1-d6432407755b
DOI: 10.1101/2024.09.12.612764

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

G-CSF and IL-6 drive myeloid dysregulation during severe viral infectionDOI 10.1101/2024.09.12.612764Read

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19Semantic proximity Read

Suppressive myeloid cells are a hallmark of severe COVID-19Semantic proximity Read

Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitroSemantic proximity Read

A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signalingSemantic proximity Read

Induction of a regulatory myeloid program in bacterial sepsis and severe COVID-19Semantic proximity Read

Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity irrespective of virusSemantic proximity Read

Deciphering the state of immune silence in fatal COVID-19 patientsSemantic proximity Read

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.Semantic proximity Read

Comprehensive Transcriptomic Analysis of COVID-19 Blood, Lung, and AirwaySemantic proximity Read

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patientsSemantic proximity Read

People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burdenSemantic proximity Read

Transcriptome and Functions of Granulocytic Myeloid-Derived Suppressor Cells Determine their Association with Disease Severity of COVID-19Semantic proximity Read