Article

Advancing Variant Phenotyping in Myelodysplastic Syndromes via Computational Genomics of Mitochondrial Enzyme Complexes

2024-09-08

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondria are essential cellular organelles that play critical roles in hematological disorders. Recurrent mutations in mitochondrial DNA (mtDNA) have been identified in patients with myelodysplastic syndromes (MDS) and serve as significant prognostic indicators for their outcomes following allogeneic hematopoietic stem-cell transplantation (allo-HCT). However, the biological mechanisms of mt...

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Literature Corpus work: bc0734bf-5fc8-54b0-8e0c-32adf8cad5f5
DOI: 10.1101/2024.09.04.611279

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