Article

Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions

2024-04-05

Abstract excerpt

<h4>ABSTRACT</h4> ( R,S )-ketamine (ketamine) has rapid and sustained antidepressant (AD) efficacy at sub-anesthetic doses in depressed patients. A metabolite of ketamine, including ( 2R,6R )-hydroxynorketamine (( 6 )-HNKs) has been reported to exert antidepressant actions in rodent model of anxiety/depression. To further understand the specific role of ketamine’s metabolism in the AD actions of the drug, we e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bbe87fd6-1255-5f69-b7ef-43f3af1dca2d
DOI: 10.1101/2024.04.03.587904

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actionsDOI 10.1101/2024.04.03.587904Read

Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants.Semantic proximity Read

( <i>2R,6R</i> )-hydroxynorketamine facilitates extinction and prevents emotional impairment and stress-induced reinstatement in morphine abstinent miceSemantic proximity Read

Neurometabolite changes in response to antidepressant medication: a systematic review of<sup>1</sup>H-MRS findingsSemantic proximity Read

Oral esketamine in patients with treatment-resistant depression: a double-blind, randomized, placebo-controlled trial with open-label extensionSemantic proximity Read

Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF) expression level in the hippocampus.Semantic proximity Read

Ketamine, an Old–New Drug: Uses and AbusesSemantic proximity Read

In vivo and ex vivo evidence for ketamine‐induced hyperglutamatergic activity in the cerebral cortex of the rat: Potential relevance to schizophreniaSemantic proximity Read

Ketamine in severe, highly treatment-resistant depression—a retrospective case study and a perspectiveSemantic proximity Read

Ketamine Reimagined: Distinguishing Psychedelic and Psycholytic Modalities for Next-Generation Therapies.Semantic proximity Read

Treatment response to low-dose ketamine infusion for treatment-resistant depression: A gene-based genome-wide association study.Semantic proximity Read

The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro.Semantic proximity Read

Neurochemical and Neurophysiological Effects of Intravenous Administration of <i>N,N</i> -Dimethyltryptamine in RatsSemantic proximity Read