Article

Biological and physiological properties of reverse ankyrin engineered for dimer construction to enhance HIV-1 capsid interaction

2021-10-15

Abstract excerpt

Assembly and budding in the late-stage of human immunodeficiency virus type 1 (HIV-1) production relies on the polymerization of Gag protein at the inner leaflet of the plasma membrane. We previously generated an ankyrin repeat protein (Ank1D4) that specifically interacts with the CAp24 protein. This study aimed to improve the binding activity of Ank1D4 by generating two platforms for the Ank1D4 dimer. The design...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bbe6f9f0-be61-5a30-bbb7-e50e02f29ebb
DOI: 10.22541/au.163432349.99058162/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Biological and physiological properties of reverse ankyrin engineered for dimer construction to enhance HIV-1 capsid interactionDOI 10.22541/au.163432349.99058162/v1Read

Crystal structure of an antiviral ankyrin targeting the HIV-1 capsid and molecular modeling of the ankyrin-capsid complex.Semantic proximity Read

Performance of Affinity-Improved DARPin Targeting HIV Capsid Domain in Interference of Viral Progeny Production.Semantic proximity Read

Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and TherapySemantic proximity Read

Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.Semantic proximity Read

Designed Ankyrin Repeat Proteins: A New Class of Viral Entry InhibitorsSemantic proximity Read

A trimer of dimers is the basic building block for human immunodeficiency virus-1 capsid assembly.Semantic proximity Read

CD4-Specific Designed Ankyrin Repeat Proteins Are Novel Potent HIV Entry Inhibitors with Unique CharacteristicsSemantic proximity Read

The identification of immunodominant linear epitopes of dengue type 2 virus capsid and NS4a proteins using pin-bound peptidesSemantic proximity Read

Improvement of LysM-Mediated Surface Display of Designed Ankyrin Repeat Proteins (DARPins) in Recombinant and Nonrecombinant Strains of Lactococcus lactis and Lactobacillus SpeciesSemantic proximity Read

Structural basis of diverse membrane target recognitions by ankyrins.Semantic proximity Read

Structure-based rational design of a Toll-like receptor 4 (TLR4) decoy receptor with high binding affinity for a target protein.Semantic proximity Read

Creating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion InhibitorsSemantic proximity Read