Article
FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes.
Scientific reports - 25 May 2016
Kuga Takahisa, Sasaki Mitsuho, Mikami Toshinari, Miake Yasuo, Adachi Jun, Shimizu Maiko, Saito Youhei, Koura Minako, Takeda Yasunori, Matsuda Junichiro, Tomonaga Takeshi, Nakayama Yuji
Abstract excerpt
FAM83H is essential for the formation of dental enamel because a mutation in the FAM83H gene causes amelogenesis imperfecta (AI). We previously reported that the overexpression of FAM83H often occurs and disorganizes the keratin cytoskeleton in colorectal cancer cells. We herein show that FAM83H regulates the organization of the keratin cytoskeleton and maintains the formation of desmosomes in ameloblastoma...
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