Human Telomere Structure and Biology

doi:10.1146/annurev.genom.8.021506.172017

Article

Human Telomere Structure and Biology

8 May 2008

Abstract excerpt

Human telomeric DNA is complex and highly variable. Subterminal sequences are associated with cis-acting determinants of allele-specific (TTAGGG)n tract length regulation and may modulate susceptibility of (TTAGGG)n tracts to rapid deletion events. More extensive subtelomeric DNA tracts are filled with segmental duplications and segments that vary in copy number, leading to highly variable subtelomeric allele...

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