Article

Comprehensive Transcriptomic Analysis and Biomarker Prioritization of Hydroxyprogesterone in Breast Cancer

2025-12-24

Abstract excerpt

Hydroxyprogesterone (HP) is a synthetic progestogen widely used in obstetric care, and its potential influence on breast cancer biology has become an emerging area of interest. Despite its clinical use, the molecular mechanisms by which HP affects tumor tissue remain insufficiently explored. In this study, transcriptomic profiling was performed to investigate gene expression changes associated with HP in operable...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bb4aa836-c5fa-55a2-802a-739091e6dcfa
DOI: 10.20944/preprints202512.2248.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comprehensive Transcriptomic Analysis and Biomarker Prioritization of Hydroxyprogesterone in Breast CancerDOI 10.20944/preprints202512.2248.v1Read

Genome-Wide Progesterone Receptor Binding: Cell Type-Specific and Shared Mechanisms in T47D Breast Cancer Cells and Primary Leiomyoma CellsSemantic proximity Read

Androgen receptor-mediated pharmacogenomic expression quantitative trait loci: implications for breast cancer response to AR-targeting therapy.Semantic proximity Read

Depletion of BRCA1 Potentiates Progestin-Induced Cytoskeletal Changes in an Ovarian Cancer Cell ModelSemantic proximity Read

Progesterone action in breast, uterine, and ovarian cancersSemantic proximity Read

Dienogest interrupts the chemokine signalling axis in endometriotic lesions with resistant signatures providing novel opportunities for personalised treatment.Semantic proximity Read

Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programsSemantic proximity Read

Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cellsSemantic proximity Read

Decidual Disrupting Effects of Low-Dose Benzophenone-Type UV Filters in Human Endometrial Stromal Cells via ER/PR/FOXO1 SignalingSemantic proximity Read

Genetic prediction of long-term effects of aromatase inhibition on cancer and non-neoplastic disease riskSemantic proximity Read

Dynamic Transcriptome, Accessible Genome and PGR Cistrome Profiles in the Human MyometriumSemantic proximity Read

Steroidogenic Enzyme and Key Decidualization Marker Dysregulation in Endometrial Stromal Cells from Women with Versus Without Endometriosis1Semantic proximity Read

Biology of breast cancer during pregnancy using genomic profiling.Semantic proximity Read