Article

Identification of multiple large deletions in ORF7a resulting in in-frame gene fusions in clinical SARS-CoV-2 isolates

2020-06-09

Abstract excerpt

Peculiar among human RNA viruses, coronaviruses have large genomes containing accessory genes that are not required for replication. Numerous mutations within the SARS-CoV-2 genome have been described but few deletions in the accessory genes of SARS-CoV-2 have been reported. Here, we report two large deletions in ORF7a, both of which produce new open reading frames (ORFs) through the fusion of the N-terminus of OR...

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Literature Corpus work: bb28a44d-74f1-51e8-9445-d0b9e7a97c74
DOI: 10.1101/2020.06.08.20125856

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