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A cross-species study of sex chromosome dosage effects on mammalian brain anatomy

2022-09-01

Abstract excerpt

<h4>Summary</h4> All eutherian mammals show chromosomal sex determination with contrasting sex chromosome dosages (SCDs) between males (XY) and females (XX). Studies in transgenic mice and humans with sex chromosome trisomy (SCT) have revealed direct SCD effects on regional mammalian brain anatomy, but we lack a formal test for cross-species conservation of these effects. Here, we develop a harmonized framework f...

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Literature Corpus work
bb0da2c2-554f-5b8e-ab1a-9c7e21393f8e
DOI
10.1101/2022.08.30.505916
Open publication

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A cross-species study of sex chromosome dosage effects on mammalian brain anatomyDOI 10.1101/2022.08.30.505916
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