Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

X-chromosome influences on neuroanatomical variation in humans.

Nature neuroscience - 1 Sept 2021

Mallard Travis T, Liu Siyuan, Seidlitz Jakob, Ma Zhiwei, Moraczewski Dustin, Thomas Adam, Raznahan Armin

Abstract excerpt

The X-chromosome has long been hypothesized to have a disproportionate influence on the brain based on its enrichment for genes that are expressed in the brain and associated with intellectual disability. Here, we verify this hypothesis through partitioned heritability analysis of X-chromosome influences (XIs) on human brain anatomy in 32,256 individuals from the UK Biobank. We first establish evidence for dosage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Chromosomes, Human, X
Share to Dosage Compensation, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, X-Linked

Share to Genome-Wide Association Study

Share to Genotype

Share to Magnetic Resonance Imaging

Share to Sex Characteristics

Source

Identifiers

PMID: 34294918
DOI: 10.1038/s41593-021-00890-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

X-chromosome influences on neuroanatomical variation in humans.PMID 34294918Read ↗

The pivotal role of the X-chromosome in the genetic architecture of the human brainSemantic proximity Read ↗

A sex-stratified analysis of the genetic architecture of human brain anatomySemantic proximity Read ↗

A sex-stratified analysis of the genetic architecture of human brain anatomy.Semantic proximity Read ↗

Fractionation of sex differences in human cortical anatomySemantic proximity Read ↗

Using neuroimaging genomics to investigate the evolution of human brain structure.Semantic proximity Read ↗

A cross-species study of sex chromosome dosage effects on mammalian brain anatomySemantic proximity Read ↗

The Effects of X Chromosome Loss on Neuroanatomical and Cognitive Phenotypes During Adolescence: a Multi-modal Structural MRI and Diffusion Tensor Imaging Study.Semantic proximity Read ↗

The Evolutionary History of Common Genetic Variants Influencing Human Cortical Surface Area.Semantic proximity Read ↗

Gonadal and sex chromosomal contributions to sex differences in mammalian brain organizationSemantic proximity Read ↗

Sex Differences in the Human Brain and the Impact of Sex Chromosomes and Sex HormonesSemantic proximity Read ↗

X- vs. Y-chromosome dosage effects on human cognition: a deep phenotypic comparison of 47,XXY and 47,XYY syndromes.Semantic proximity Read ↗

Emerging X-linked genes associated with neurodevelopmental disorders in females.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.