Article

Synergistic Inhibition of PI3K and HSP90 Enhanced Antitumorigenic Efficacy in Adrenocortical Carcinoma

2025-11-01

Abstract excerpt

<title>Abstract</title> <p> Adrenocortical cancer (ACC) is a rare and aggressive malignancy with poor survival due to a lack of effective treatments; therefore, it is important to identify therapies to be readily studied in clinical trials. Quantitative high-throughput drug combination screening identified potent synergy between phosphatidylinositol-3-kinase (PI3K) inhibitor, PIK75 and heat shock protein 90 (HSP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bae7d904-e87d-5f71-ab3b-6f6fd1b7a918
DOI: 10.21203/rs.3.rs-7761877/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Synergistic Inhibition of PI3K and HSP90 Enhanced Antitumorigenic Efficacy in Adrenocortical CarcinomaDOI 10.21203/rs.3.rs-7761877/v1Read

Preclinical Assessment of Synergistic Efficacy of MELK and CDKs inhibitors in Adrenocortical CancerSemantic proximity Read

Adrenocortical Carcinoma Steroid Profiles: In Silico Pan-Cancer Analysis of TCGA Data Uncovers Immunotherapy Targets for Potential Improved OutcomesSemantic proximity Read

Molecular markers and targeted therapies for adrenocortical carcinoma.Semantic proximity Read

A Rational Drug Combination Design to Inhibit Epithelial-Mesenchymal Transition in a Three-Dimensional MicroenvironmentSemantic proximity Read

KIAA0101 is overexpressed, and promotes growth and invasion in adrenal cancer.Semantic proximity Read

Drug combinations with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroidsSemantic proximity Read

Establishment of a patient-derived adrenocortical carcinoma 3D tumor construct platform for evaluation of therapeutic strategiesSemantic proximity Read

Antitumor Effects and Biomarkers of Activity of AZD0530, a Src Inhibitor, in Pancreatic CancerSemantic proximity Read

Targeted Gene Expression Profile Reveals CDK4 as Therapeutic Target for Selected Patients With Adrenocortical CarcinomaSemantic proximity Read

A high-throughput drug combination screen identifies an anti-glioma synergism between TH588 and PI3K inhibitorsSemantic proximity Read

A Pan-Cancer Analysis of Heat-Shock Protein 90 Beta1(HSP90B1) in Human TumoursSemantic proximity Read

Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma TreatmentSemantic proximity Read