Article

Preclinical Assessment of Synergistic Efficacy of MELK and CDKs inhibitors in Adrenocortical Cancer

2022-05-16

Abstract excerpt

<title>Abstract</title> <p>Background Adrenocortical cancer (ACC) is a rare and aggressive cancer with dismal 5-year survival due to a lack of effective treatments. We aimed to identify a new effective combination of drugs and investigated their synergistic efficacy in ACC preclinical models. Methods A quantitative high-throughput drug screening of 4,991 compounds was performed on two ACC cell lines, SW13 and N...

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Literature Corpus work: cf015cc5-2e84-51e4-8ebb-84c20f6093ba
DOI: 10.21203/rs.3.rs-1631195/v1

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