Article

The Pattern of Cardiac Remodeling in Pediatric and Adolescent Patients with Sickle Cell Disease and the Association with the Genotype and the Clinical Severity of the Disease: A Systematic Review

2026-05-11

Abstract excerpt

<h4>Background: </h4> Sickle cell disease (SCD) is the most common inherited blood disorder globally, affecting approximately 300,000 newborns annually. Cardiac remodeling, resulting from chronic anemia, vascular obstruction, and endothelial dysfunction, substantially contributes to morbidity and mortality in SCD. Apprehending these patterns is important for guiding clinical management and enhancing outcomes in pe...

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Literature Corpus work: ba886c30-2445-52af-ac4d-9924e533f130
DOI: 10.20944/preprints202605.0583.v1

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