Article

LncRNA NDRG1 aggravates progression and EMT of osteosarcoma by sponging miR-96-5p through the PI3K/AKT pathway

2022-03-08

Abstract excerpt

<h4>Background: </h4> Osteosarcoma (OS) is the most common primary malignant bone tumors in adolescents. Large numbers of studies have focused on the long non-coding RNA (lncRNA) that plays essential roles in the progression of osteosarcoma. Nevertheless, the functions and underlying mechanisms of LncRNA NDRG1 in osteosarcoma remain unknown. Methods By ways of RNA sequencing, lncRNAs which expressed differentiall...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ba6b0f84-1f35-5df9-98eb-fb087ec37fec
DOI: 10.21203/rs.3.rs-1358250/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LncRNA NDRG1 aggravates progression and EMT of osteosarcoma by sponging miR-96-5p through the PI3K/AKT pathwayDOI 10.21203/rs.3.rs-1358250/v1Read

miR-766-3p suppressed tumorigenesis, epithelial-mesenchymal transition, and metastasis by targeting BCL9L via β -catenin signaling pathway in osteosarcoma cellsSemantic proximity Read

m6A-dependent up-regulation of DRG1 by METTL3 and ELAVL1 promotes growth, migration, and colony formation in osteosarcomaSemantic proximity Read

Long non-coding RNAs in osteosarcomaSemantic proximity Read

CA9 is an important molecular marker for the prognosis of osteosarcoma patientsSemantic proximity Read

Silencing of SNHG6 induced cell autophagy by targeting miR-26a-5p/ULK1 signaling pathway in human osteosarcomaSemantic proximity Read

LncRNA GAS5 suppresses the proliferation and invasion of osteosarcoma cells via the miR-23a-3p/PTEN/PI3K/AKT pathwaySemantic proximity Read

Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancerSemantic proximity Read

Multifaceted and Intricate Oncogenic Mechanisms of NDRG1 in Head and Neck Cancer Depend on Its C-Terminal 3R-MotifSemantic proximity Read

Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcomaSemantic proximity Read

Long non-coding RNA PGM5-AS1 modulates epithelial-mesenchymal transition and invasion and metastasis of osteosarcoma cells by impairing miR-140-5p-mediated FBN1 inhibitionSemantic proximity Read

<i>LINC00968</i> functions as an oncogene in osteosarcoma by activating the PI3K/AKT/mTOR signalingSemantic proximity Read

NDRG1 in Cancer: A Suppressor, Promoter, or Both?Semantic proximity Read