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The annotation and function of the Parkinson’s and Gaucher disease-linked gene <i>GBA1</i> has been concealed by its protein-coding pseudogene <i>GBAP1</i>

2022-10-21

Abstract excerpt

<h4>ABSTRACT</h4> The human genome contains numerous duplicated regions, such as parent-pseudogene pairs, causing sequencing reads to align equally well to either gene. The extent to which this ambiguity complicates transcriptomic analyses is currently unknown. This is concerning as many parent genes have been linked to disease, including GBA1, causally linked to both Parkinson’s and Gaucher disease. We find tha...

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Literature Corpus work
ba17379d-9833-5f4f-b8c4-ff142e62e69e
DOI
10.1101/2022.10.21.513169
Open publication

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The annotation and function of the Parkinson’s and Gaucher disease-linked gene <i>GBA1</i> has been concealed by its protein-coding pseudogene <i>GBAP1</i>DOI 10.1101/2022.10.21.513169
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