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Transcriptional Variabilities in Human hiPSC-derived Cardiomyocytes: All Genes Are Not Equal and Their Robustness May Foretell Donor’s Disease Susceptibility

2024-04-21

Abstract excerpt

<h4>SUMMARY</h4> Human induced pluripotent stem cells (hiPSCs) are frequently used to study disease-associated variations. We characterized transcriptional variability from a hiPSC-derived cardiomyocyte (hiPSC-CM) study of left ventricular hypertrophy (LVH) using donor samples from the HyperGEN study. Multiple hiPSC-CM differentiations over reprogramming events (iPSC generation) across 7 donors were used to asses...

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Literature Corpus work
b9e95044-4723-58d3-9328-9e6b4f9e892b
DOI
10.1101/2024.04.18.584138
Open publication

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Transcriptional Variabilities in Human hiPSC-derived Cardiomyocytes: All Genes Are Not Equal and Their Robustness May Foretell Donor’s Disease SusceptibilityDOI 10.1101/2024.04.18.584138
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