Article
Myelodysplastic syndromes with del(5q): indications and strategies for cytogenetic testing.
Cancer genetics and cytogenetics - 1 Dec 2008
Haferlach Claudia, Bacher Ulrike, Tiu Ramon, Maciejewski Jaroslaw P, List Alan
Abstract excerpt
Cytogenetics is a major predictor of disease behavior and treatment outcome in myelodysplastic syndromes (MDS). Deletion of the long arm of chromosome 5, del(5q), is the most common chromosomal abnormality found in patients with MDS. The development of lenalidomide (Revlimid; Celgene, Summit, NJ) as an effective targeted therapy for low/intermediate-risk MDS with a del(5q) has increased the importance of...
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