Article
Identification of Genetic Variants in Progressive Supranuclear Palsy in Southeast Asia.
Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2024
Ng Adeline Su Lyn, Tan Ai Huey, Tan Yi Jayne, Lim Jia Lun, Lian Michelle Mulan, Dy Closas Alfand Marl, Ahmad-Annuar Azlina, Viswanathan Shanthi, Chia Yuen Kang, Foo Jia Nee, Lim Weng Khong, Tan Eng-King, Lim Shen-Yang
Abstract excerpt
BACKGROUND: Progressive supranuclear palsy (PSP) is largely a sporadic disease with few reported familial cases. Genome-wide association studies (GWAS) in sporadic PSP in Caucasian populations have identified MAPT as the most commonly associated genetic risk locus with the strongest effect size. At present there are limited data on genetic factors associated with PSP in Asian populations. OBJECTIVES: Our goal was...
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