Article

CD81 partners with CD44 in promoting exosome biogenesis, tumor cluster formation, and lung metastasis in triple negative breast cancer

2022-02-25

Abstract excerpt

Tumor-initiating cells with reprogramming plasticity are thought to be essential for cancer development and metastatic regeneration in many cancers; however, the molecular mechanisms are not fully understood. This study reports that CD81, a tetraspanin protein marker of small extracellular vesicles (exosomes), functions as a binding partner of CD44 and facilitates self-renewal of tumor initiating cells. Using mach...

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Identifiers and source

Literature Corpus work: b7b62460-dcca-5cea-aa32-561df6b2b8a2
DOI: 10.1101/2022.02.23.481674

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