Article

HLA Class II Alleles are associated with Anti-Drug Antibodies in Ulcerative Colitis Patients Treated with Etrolizumab

2025-03-28

Abstract excerpt

Patients treated with etrolizumab, a monoclonal antibody drug for ulcerative colitis, often develop anti-drug antibodies (ADA) and neutralizing antibodies (NAb). To investigate genetic risk factors, we evaluated associations between HLA alleles and ADA/NAb development. HLA-DQB1*06:03 demonstrated the most significant association with both ADA (OR = 7.3, P ≤ 7.6×10 −13 ) and NAb (OR = 13.1, P ≤ 7.7×10 −13 ). After...

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Literature Corpus work: b752d4b0-ae02-545d-8a74-587ebd83ff3f
DOI: 10.1101/2025.03.28.25320486

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