Article

Novel interferon-gamma-related 2-gene signature predicts outcome and responsiveness to immune checkpoint blockade in glioma

2021-10-11

Abstract excerpt

<h4>Background: </h4> Glioma represents the most common and aggressive brain malignancy. Interferon-gamma (IFNG)-related gene signatures have been shown of clinical significance in multiple cancers, while its role in glioma remains less addressed. Methods A total of 2933 glioma samples ranging from WHO grade II to IV with corresponding demographics were included. Multiple bioinformatics and machine learning algor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b73a22cb-df7c-5b43-bf88-e8e1704d5dc3
DOI: 10.21203/rs.3.rs-936690/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel interferon-gamma-related 2-gene signature predicts outcome and responsiveness to immune checkpoint blockade in gliomaDOI 10.21203/rs.3.rs-936690/v1Read

Interferon gamma-related gene signature based on anti-tumor immunity predicts glioma patient prognosisSemantic proximity Read

Construction of Interferon-Gamma-Related Gene Signature to Characterize the Immune-Inflamed Phenotype of Glioblastoma and Predict Prognosis, Efficacy of Immunotherapy and Radiotherapy.Semantic proximity Read

A Prognostic DNA Damage Repair Genes Signature and Its Impact on Immune Cell Infiltration in GliomaSemantic proximity Read

A novel DNA damage and repair-related gene signature to improve predictive capacity of overall survival for patients with gliomas.Semantic proximity Read

Identification and Validation of RNA Methylation-Related Related Alternative Splicing Gene Signature for Low Grade Glioma to Predict Survival and Immune LandscapesSemantic proximity Read

Molecular and clinicopathological characterization of a prognostic immune gene signature associated with MGMT methylation in glioblastomaSemantic proximity Read

Predictive Panel for Immunotherapy in Low-Grade Glioma.Semantic proximity Read

A specific immune signature for predicting the prognosis of glioma patients with IDH1-mutation and guiding immune checkpoint blockade therapy.Semantic proximity Read

Comprehensive Molecular Analyses of a Novel Mutational Signature Classification System with Regard to Prognosis, Genomic Alterations, and Immune Landscape in GliomaSemantic proximity Read

Genomic Profiling of lower-grade gliomas subtype with distinct molecular and clinicopathologic characteristics via altered DNA-damage repair featuresSemantic proximity Read

Development and Validation of a Glioma-Associated Mesenchymal Stem Cell-Related Gene Prognostic Index for Predicting Prognosis and Guiding Individualized Therapy in GliomaSemantic proximity Read