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Specific detection of cell-free DNA derived from intestinal epithelial cells using methylation patterns

2018-09-05

Abstract excerpt

Epithelial cells of the intestine undergo rapid turnover and are thought to be cleared via stool. Disruption of tissue architecture, as occurs in colorectal cancer (CRC), results in the release of material from dying intestinal epithelial cells to blood. This phenomenon could be utilized for diagnosis and monitoring of intestinal diseases, if circulating cell-free DNA (cfDNA) derived from intestinal cells could be...

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Literature Corpus work
b733b5ad-560c-5b1a-af6f-d67ecef25170
DOI
10.1101/409219
Open publication

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Specific detection of cell-free DNA derived from intestinal epithelial cells using methylation patternsDOI 10.1101/409219
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