Article

Lymph node macrophage-targeted interferon alpha boosts anticancer immune responses by regulating CD169-positive phenotype of macrophages

2024-10-15

Abstract excerpt

<title>Abstract</title> <bold>Background</bold> CD169+ macrophages in lymph nodes (LNs) activate cytotoxic T lymphocytes (CTLs), which play a crucial role in anticancer immunity, through antigen presentation and co-stimulation by CD169. Interferon alpha (IFNα) is capable of inducing the CD169+ phenotype of macrophages; however, its clinical applications have been hindered by pharmacokinet...

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Literature Corpus work: b68b1098-3ea5-5513-a9f8-5605b751e44f
DOI: 10.21203/rs.3.rs-4946728/v1

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